Title: Microsatellite instable and microsatellite stable primary endometrial carcinoma cells and their subcutaneous and orthotopic xenografts recapitulate the characteristics of the corresponding primary tumor
Authors: Schrauwen, Stefanie ×
Coenegrachts, Lieve
Depreeuw, Jeroen
Luyten, Catherina
Verbist, Godelieve
Debruyne, David
Vergote, Ignace
Lambrechts, Diether
Amant, Frédéric #
Issue Date: Mar-2015
Publisher: Blackwell Scientific Publications
Series Title: International Journal of Gynecological Cancer vol:25 issue:3 pages:363-71
Article number: 10.1097/IGC.0000000000000363
Abstract: Well-characterized, low-passage, primary cell cultures established directly from patient tumors are an important tool for drug screening because these cultures faithfully recapitulate the genomic features of primary tumors. Here, we aimed to establish these cell cultures from primary endometrial carcinomas (ECs) and to develop subcutaneous and orthotopic xenograft models as a model to validate promising treatment options for EC in the in vivo setting.
ISSN: 1048-891X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
Laboratory of Translational Genetics (Vesalius Research Center) (+)
Department of Oncology - miscellaneous
× corresponding author
# (joint) last author

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