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Title: Renal function in children and adolescents with Duchenne muscular dystrophy
Authors: Braat, Elke ×
Hoste, Liesbeth
De Waele, Liesbeth
Gheysens, Olivier
Vermeersch, Pieter
Goffin, Karolien
Pottel, Hans
Goemans, Nathalie
Levtchenko, Elena #
Issue Date: Jan-2015
Publisher: Pergamon Press
Series Title: Neuromuscular Disorders vol:25 issue:5 pages:381-387
Article number: S0960-8966(15)00024-3
Abstract: Improved life expectancy and the need for robust tools to monitor renal safety of emerging new therapies have fueled the interest in renal function in Duchenne muscular dystrophy (DMD) patients. We aimed to establish a methodology to accurately assess their renal function. Twenty DMD patients (5-22 years) were included in this prospective study. After obtaining medical history, all patients underwent a clinical examination, 24-hour ambulatory blood pressure monitoring, ultrasound of the kidneys, direct GFR measurement ((51)Cr-EDTA, mGFR), complete blood and urine analysis. Seventeen of 20 patients were treated with corticosteroids and 5/20 with angiotensin converting enzyme inhibitor (lisinopril). No patient suffered from urinary tract infections or other renal diseases. Hypertension (systolic or diastolic blood pressure >P95) was found in 9/20 patients (8/9 patients were on steroid treatment) and a non-dipping blood pressure profile in 13/20 subjects (10/13 patients were on steroid treatment). Urinary protein to creatinine ratio was elevated in 17/18 patients, whereas 24-hour urine protein excretion was normal in all subjects. Median interquartile range (IQR) mGFR was 130.4 (29.1) mL/min/1.73 m(2). Hyperfiltration (mGFR >150 mL/min/1.73 m(2)) was found in 5/20 patients. Inverse correlation between mGFR and age was observed (R(2) = 0.45, p = 0.001). Serum creatinine based estimated GFR (eGFR) equations overestimated mGFR up to 300%. eGFR based on cystatin C Filler equation was closest to the mGFR (median eGFR (IQR) of 129.5 (39.7) mL/min/1.73 m(2)). Our study demonstrates a high prevalence of hyperfiltration and hypertension in children and adolescents with DMD. Because the majority of hypertensive patients were under corticosteroid treatment, the iatrogenic cause of hypertension cannot be excluded. Serum or urine creatinine measurements are of no value to evaluate renal function in DMD patients due to the reduced skeletal muscle mass.
ISSN: 0960-8966
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Public Health and Primary Care, Campus Kulak Kortrijk
Development and Regeneration, Campus Kulak Kortrijk
Nuclear Medicine & Molecular Imaging
Cardiology
Organ Systems (+)
× corresponding author
# (joint) last author

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