Title: The tumor necrosis factor superfamily members TWEAK, TNFSF15 and fibroblast growth factor-inducible protein 14 are upregulated in proliferative diabetic retinopathy
Authors: Abu El-Asrar, Ahmed M ×
De Hertogh, Gert
Nawaz, Mohd Imtiaz
Siddiquei, Mohammad Mairaj
Van den Eynde, Kathleen
Mohammad, Ghulam
Opdenakker, Ghislain
Geboes, Karel #
Issue Date: Feb-2015
Publisher: S. Karger
Series Title: Ophthalmic Research vol:53 issue:3 pages:122-30
Article number: 10.1159/000369300
Abstract: Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and tumor necrosis factor superfamily member 15 (TNFSF15), members of the TNF superfamily, play important roles in the modulation of inflammation and neovascularization. TWEAK activity is mediated via binding to fibroblast growth factor-inducible molecule 14 (Fn14). We investigated the expression of TWEAK, Fn14 and TNFSF15 and the correlation between TWEAK levels and the levels of the inflammatory biomarker soluble intercellular adhesion molecule-1 (sICAM-1) in proliferative diabetic retinopathy (PDR). In addition, we examined the expression of FN14 and TNFSF15 in retinas of diabetic rats.
ISSN: 0030-3747
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Immunobiology (Rega Institute)
Translational Cell & Tissue Research
× corresponding author
# (joint) last author

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