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Title: Facile Access to Functionalized Spiro[indoline-3,2 '-pyrrole]-2,5 '-diones via Post-Ugi Domino Buchwald-Hartwig/Michael Reaction
Authors: Sharma, Nandini * ×
Li, Zhenghua *
Sharma, Upendra K
Van der Eycken, Erik #
Issue Date: 16-Jul-2014
Publisher: American Chemical Society
Series Title: Organic Letters vol:16 issue:15 pages:3884-3887
Abstract: A novel access to spiro[indoline-3,2′-pyrrole]-2,5′-diones is presented via a palladium-catalyzed post-Ugi cascade cyclization approach involving a Buchwald–Hartwig/Michael reaction sequence. The method allows the easy construction of a library of spirooxindoles in moderate to good yields starting from readily available precursors. In addition, alkynoic acids are replaced with α,β-unsaturated acids leading to variably substituted spirooxindoles.
ISSN: 1523-7060
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
* (joint) first author
× corresponding author
# (joint) last author

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