Title: Assembly of a 1H-Pyrrol-2(5H)-one Core through a Cascade Ugi Reaction/5-endo-dig Carbocyclization/Retro-Claisen Fragmentation Process
Authors: Peshkov, Anatoly ×
Peshkov, Vsevolod
Li, Zhenghua
Pereshivko, Olga P
Van der Eycken, Erik # ×
Issue Date: 15-Sep-2014
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:29 pages:6390-6393
Abstract: A cascade transformation involving the Ugi reaction followed by 5-endo-dig carbocyclization and retro-Claisen fragmentation providing access to a 1H-pyrrol-2(5H)-one core is described. The operating protocol is very similar to the typical Ugi reaction settings, while the overall outcome results from the application of a 3-substituted propiolic acid and a phenylglyoxal as acid and aldehyde components, respectively. The utility of process is demonstrated through the synthesis of a small library of 5-oxo-2,5-dihydro-1H-pyrrole-2-carboxamides.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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