Author:

Keywords:

biosensors, electrochemical analysis, impedance spectroscopy, molecular imprinting, Science & Technology, Technology, Physical Sciences, Materials Science, Multidisciplinary, Physics, Applied, Physics, Condensed Matter, Materials Science, Physics, LABEL-FREE, HISTAMINE, DIAMOND, 0204 Condensed Matter Physics, 0912 Materials Engineering, 1007 Nanotechnology, Applied Physics, 4016 Materials engineering, 4018 Nanotechnology, 5104 Condensed matter physics

Abstract:

A miniaturised, low cost impedance analyser is developed to ease the use of impedance spectroscopy in biological setups. This could form the first step towards fully standalone, hand-held biosensor applications. The system is capable of performing quasi-simultaneous time resolved impedance measurements on eight different channels in a frequency range of 10Hz-100kHz. The unit is accurate in a broad impedance range and is able to perform stable measurements over intervals of several days. The system is characterised by passive components, a temperature controlled wet cell based impedance setup and a biomimetic molecularly imprinted polymer (MIP) based histamine sensor. The test results all indicate accurate and stable functioning of the unit, making it suitable for bioanalytical applications. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.