Title: In vivo and in vitro evidence that ⁹⁹mTc-HYNIC-interleukin-2 is able to detect T lymphocytes in vulnerable atherosclerotic plaques of the carotid artery
Authors: Glaudemans, Andor W J M ×
Bonanno, Elena
Galli, Filippo
Zeebregts, Clark J
de Vries, Erik F J
Koole, Michel
Luurtsema, Gert
Boersma, Hendrikus H
Taurino, Maurizio
Slart, Riemer H J A
Signore, Alberto #
Issue Date: Sep-2014
Series Title: European Journal of Nuclear Medicine and Molecular Imaging vol:41 issue:9 pages:1710-9
Article number: 10.1007/s00259-014-2764-0
Abstract: Recent advances in basic science have established that inflammation plays a pivotal role in the pathogenesis of atherosclerosis. Inflammatory cells are thought to be responsible for the transformation of a stable plaque into a vulnerable one. Lymphocytes constitute at least 20 % of infiltrating cells in these vulnerable plaques. Therefore, the interleukin-2 (IL-2) receptor, being overexpressed on activated T lymphocytes, may represent an attractive biomarker for plaque vulnerability. The aim of this study was to evaluate the specificity of radiolabelled IL-2 [(99m)Tc-hydrazinonicotinamide (HYNIC)-IL-2] for imaging the lymphocytic infiltration in carotid plaques in vivo by planar and single photon emission computed tomography (SPECT)/CT imaging and ex vivo by microSPECT and autoradiography.
ISSN: 1619-7070
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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