Dynamics of tumor hypoxia assessed by 18F-FAZA PET/CT in head and neck and lung cancer patients during chemoradiation: possible implications for radiotherapy treatment planning strategies
Bollineni, Vikram R × Koole, Michel Pruim, Jan Brouwer, Charlotte L Wiegman, Erwin M Groen, Harry J M Vlasman, Renske Halmos, Gyorgy B Oosting, Sjoukje F Langendijk, Johannes A Widder, Joachim Steenbakkers, Roel J H M #
Elsevier Science Publishers
Radiotherapy and Oncology vol:113 issue:2 pages:198-203
To define the optimal time point for the integration of hypoxia (18)F-FAZA-PET/CT information into radiotherapy treatment planning to benefit from hypoxia modification or dose escalation treatment. Therefore, we performed a prospective cohort study, using serial hypoxic imaging ((18)F-FAZA-PET/CT) prior to and at several time-points during (chemo)radiotherapy (CHRT) in six head and neck squamous cell (HNSCC) and six non-small cell lung cancer (NSCLC) patients.