Author:

Keywords:

Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Respiratory System, Surgery, Cardiovascular System & Cardiology, STRUCTURAL VALVE DEGENERATION, PROSTHESIS-PATIENT MISMATCH, BIOPROSTHETIC HEART-VALVES, PORCINE AORTIC-VALVE, BOVINE PERICARDIUM, VALVULAR BIOPROSTHESES, CALCIFICATION, GLUTARALDEHYDE, REPLACEMENT, CUSPS, Age Factors, Animals, Bioprosthesis, Calcinosis, Calcium, Female, Glycerol, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Hemodynamics, Mitral Valve, Models, Animal, Prosthesis Design, Radiography, Random Allocation, Sheep, Time Factors, Tissue Preservation, Ultrasonography, 1102 Cardiorespiratory Medicine and Haematology, 1103 Clinical Sciences, 3201 Cardiovascular medicine and haematology, 3202 Clinical sciences

Abstract:

Despite improved anticalcification technology, bioprosthetic heart valves still cannot be used in younger patients because of progressive structural valve degeneration. A novel advanced tissue preservation technology was developed that uses stable functional group capping and preservation by glycerolization. Valves incorporating this novel technology can be stored in a dry condition and do not require rinsing before use. The aim of the study was to assess the effects of this new technology in terms of valve function and durability in a chronic sheep model of orthotopic implantation.