Title: [Penetration and action of edoxudine in vitro and in vivo]
Authors: Kaul, R ×
Hempel, B
De Clercq, Erik #
Issue Date: Mar-1989
Publisher: Editio Cantor
Series Title: Arzneimittel-Forschung vol:39 issue:3 pages:366-8
Abstract: The penetration of 5-ethyl-2'-deoxyuridine (edoxudine, Aedurid) from gel base with and without the addition of urea and other adjuvant has been studied in an in vitro model using guinea pig skin. The formulation of 3% edoxudine gel with 5% urea showed the best results. In vivo experiments on hairless mice infected intracutaneously with herpes simplex virus type 1 also showed this formulation's good efficacy as compared to other formulations.
ISSN: 0004-4172
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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