Title: Emotional disorders in adult mice heterozygous for the transcription factor Phox2b
Authors: Bollen, Bieke ×
Ramanantsoa, Nelina
Naert, Arne
Matrot, Boris
Van den Bergh, Omer
D'Hooge, Rudi
Gallego, Jorge #
Issue Date: Jan-2015
Publisher: Pergamon Press
Series Title: Physiology & Behavior vol:141 pages:120-126
Article number: S0031-9384(15)00026-8
Abstract: Phox2b is an essential transcription factor for the development of the autonomic nervous system. Mice carrying one invalidated Phox2b allele (Phox2b(+/-)) show mild autonomic disorders including sleep apneas, and impairments in chemosensitivity and thermoregulation that recover within 10days of postnatal age. Because Phox2b is not expressed above the pons nor in the cerebellum, this mutation is not expected to affect brain development and cognitive functioning directly. However, the transient physiological disorders in Phox2b(+/-) mice might impair neurodevelopment. To examine this possibility, we conducted a behavioral test battery of emotional, motor, and cognitive functioning in adult Phox2b(+/-) mice and their wildtype littermates (Phox2b(+/+)). Adult Phox2b(+/-) mice showed altered exploratory behavior in the open field and in the elevated plus maze, both indicative of anxiety. Phox2b(+/-) mice did not show cognitive or motor impairments. These results suggest that also mild autonomic control deficits may disturb long-term emotional development.
ISSN: 0031-9384
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Health Psychology
Laboratory for Biological Psychology
Institute for Commercial and Insolvency Law
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
2015emotionaldisorders.pdf Published 664KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science