Title: Prophylactic treatment with the nucleoside analogue 2'-C-methylcytidine completely prevents transmission of norovirus
Authors: Rocha-Pereira, Joana ×
Jochmans, Dirk
Neyts, Johan #
Issue Date: Jan-2015
Publisher: Oxford University Press
Series Title: The Journal of Antimicrobial Chemotherapy vol:70 issue:1 pages:190-7
Article number: 10.1093/jac/dku363
Abstract: Norovirus outbreaks of acute gastroenteritis are highly prevalent, extensive and can disturb the functioning of health institutions, leading to the closure of hospital wards and causing life-threatening infections in long-term care facilities. There is no vaccine available; hence there is a pressing need for antivirals for the treatment (in immunodeficient patients) and prophylaxis of norovirus infections. We explored in a mouse model whether an inhibitor of norovirus replication can prevent/reduce transmission of the virus.
ISSN: 0305-7453
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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