Title: Exhaled nitric oxide and nasal tryptase are associated with wheeze, rhinitis and nasal allergy in primary school children
Authors: De Prins, Sofie ×
Marcucci, Francesco
Sensi, Laura
Van de Mieroop, Els
Nelen, Vera
Nawrot, Tim
Schoeters, Greet
Koppen, Gudrun #
Issue Date: Sep-2014
Publisher: Taylor & Francis
Series Title: Biomarkers vol:19 issue:6 pages:481-7
Article number: 10.3109/1354750X.2014.937362
Abstract: Rhinitis and asthma are the most common respiratory diseases in children. We assessed whether airway inflammation markers were associated with nasal allergies and self-reported symptoms of wheeze and rhinitis in 130 children 6-12 year old in an epidemiological context. Independent of sex and age, the fraction of exhaled nitric oxide (FeNO) and nasal mast cell (MC) activation (tryptase ≥ 5 ng/mL) were positively associated with wheeze, rhinitis and with nasal allergy. Nasal eosinophil cationic protein (ECP) and exhaled breath condensate (EBC) markers (pH, 8-isoprostane, interleukin-1β) were not associated with symptoms or with nasal allergy. In conclusion, FeNO and nasal tryptase reflect allergic inflammation in the respiratory system.
ISSN: 1354-750X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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