Title: Tissue-type plasminogen activator in breast cancer: relationship with estradiol and progesterone receptors
Authors: Duffy, M J ×
O'Grady, P
Simon, J
Rose, M
Lijnen, Roger #
Issue Date: Aug-1986
Series Title: Journal of the National Cancer Institute vol:77 issue:3 pages:621-3
Abstract: Plasminogen activator (PA) is an estradiol-inducible enzyme and therefore a potential marker for a functional estradiol receptor (ER) in human breast carcinomas. In this investigation tissue-type PA (t-PA) correlated significantly with both ER and progesterone receptors (PR) in human breast carcinomas. In contrast, neither total PA activity nor urokinase-like PA showed any significant correlation with either ER or PR. Other proteases such as a trypsin-like protease, a chymotrypsin-like protease, and cathepsin B also showed no correlation with ER and PR. It was concluded that the t-PA form of PA may be a marker for a functional ER in breast carcinoma and thus be of value in predicting hormone-dependent breast cancers.
ISSN: 0027-8874
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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