Title: Tissue-type plasminogen activator, a new prognostic marker in breast cancer
Authors: Duffy, M J ×
O'Grady, P
Devaney, D
O'Siorain, L
Fennelly, J J
Lijnen, Roger #
Issue Date: 1-Feb-1988
Series Title: Cancer Research vol:48 issue:5 pages:1348-9
Abstract: Plasminogen activator is a protease existing in two forms known as tissue-type and urokinase-type plasminogen activator. In this investigation, patients with breast cancers containing high levels of the tissue-type enzyme had a significantly longer disease-free interval and survival compared with patients with low levels of the enzyme. For the disease-free interval, the effect of tissue-type plasminogen activator was independent of tumor stage, grade, axillary node involvement, and estradiol receptor status. It is concluded that tissue-type plasminogen activator is a new prognostic marker in breast cancer.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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