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Title: PEAR1 is not a human hypertension-susceptibility gene
Authors: Olivi, Laura
Vandenbriele, Christophe
Gu, Yumei
Salvi, Erika
Carpini, Simona Delli
Liu, Yanping
Jacobs, Lotte
Jin, Yu
Thijs, Lutgarde
Citterio, Lorena
Cusi, Daniele
Verhamme, Peter
Staessen, Jan A # ×
Issue Date: Feb-2015
Publisher: Scandinavian University Press
Series Title: Blood Pressure vol:24 issue:1 pages:61-4
Abstract: Objective: Platelet endothelial aggregation receptor 1 (PEAR1) is a membrane protein involved in platelet contact-induced activation and sustained platelet aggregation. Experimental studies identified PEAR1, as a candidate gene that may be linked to the blood-pressure driven kidney injury in salt-sensitive Dahl rats. Aim: In a family-based European population study (mean age 39.7 years; 52.2% women), we searched for association of changes in blood pressure or incidence of hypertension with genetic variation in PEAR1. Methods: Among 1973 randomly recruited people, genotyped for PEAR1, we measured blood pressure at baseline and follow-up. Results: Median follow-up was 10.0 years. While accounting for family clusters and blood pressure at baseline and with adjustments applied for sex, age, body mass index, smoking and drinking, total cholesterol, and antihypertensive drug treatment, all associations of systolic and diastolic blood pressure changes with nine single nucleotide polymorphisms (SNPs) in PEAR1 were all non-significant (p ≥ 0.059). With similar adjustments, the incidence of hypertension (397 cases among 1532 participants were normotensive at baseline [25.9%]) was not related to the SNPs in PEAR1 (hazard ratios ≤ 1.09; p ≥ 0.09). Conclusion: Our study suggests that PEAR1 is not a hypertension susceptibility gene in humans.
ISSN: 0803-7051
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Cardiovascular Sciences - miscellaneous
Molecular and Vascular Biology
Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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