Title: Drep-2 is a novel synaptic protein important for learning and memory
Authors: Andlauer, Till F M
Scholz-Kornehl, Sabrina
Tian, Rui
Kirchner, Marieluise
Babikir, Husam A
Depner, Harald
Loll, Bernhard
Quentin, Christine
Gupta, Varun K
Holt, Matthew
Dipt, Shubham
Cressy, Michael
Wahl, Markus C
Fiala, André
Selbach, Matthias
Schwärzel, Martin
Sigrist, Stephan J # ×
Issue Date: 13-Nov-2014
Publisher: eLife Sciences
Series Title: Elife vol:3
Article number: 10.7554/eLife.03895
Abstract: CIDE-N domains mediate interactions between the DNase Dff40/CAD and its inhibitor Dff45/ICAD. In this study, we report that the CIDE-N protein Drep-2 is a novel synaptic protein important for learning and behavioral adaptation. Drep-2 was found at synapses throughout the Drosophila brain and was strongly enriched at mushroom body input synapses. It was required within Kenyon cells for normal olfactory short- and intermediate-term memory. Drep-2 colocalized with metabotropic glutamate receptors (mGluRs). Chronic pharmacological stimulation of mGluRs compensated for drep-2 learning deficits, and drep-2 and mGluR learning phenotypes behaved non-additively, suggesting that Drep 2 might be involved in effective mGluR signaling. In fact, Drosophila fragile X protein mutants, shown to benefit from attenuation of mGluR signaling, profited from the elimination of drep-2. Thus, Drep-2 is a novel regulatory synaptic factor, probably intersecting with metabotropic signaling and translational regulation.
ISSN: 2050-084X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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