Title: A chest physician's guide to mechanisms of sinonasal disease
Authors: Hox, V ×
Maes, T
Huvenne, W
Van Drunen, C
Vanoirbeek, Jeroen
Joos, G
Bachert, C
Fokkens, W
Ceuppens, Jan
Nemery, Benoit
Hellings, Peter #
Issue Date: Apr-2015
Publisher: British Medical Association
Series Title: Thorax vol:70 issue:4 pages:353-358
Article number: thoraxjnl-2014-205520
Abstract: The upper and lower airways are closely linked from an anatomical, histological and immunological point of view, with inflammation in one part of the airways influencing the other part. Despite the concept of global airway disease, the upper airways tend to be overlooked by respiratory physicians. We provide a clinical overview of the most important and recent insights in rhinitis and rhinosinusitis in relation to lower airway disease. We focus on the various exogenous and endogenous factors that play a role in the development and aggravation of chronic upper airway inflammation. In addition to the classical inhaled allergens or microorganisms with well-defined pathophysiological mechanisms in upper airway disease, environmental substances such as cigarette smoke, diesel exhaust particles and occupational agents affecting lower airway homeostasis have recently gained attention in upper airway research. We are only at the beginning of understanding the complex interplay between exogenous and endogenous factors like genetic, immunological and hormonal influences on chronic upper airway inflammation. From a clinical perspective, the involvement of upper and lower airway disease in one patient can only be fully appreciated by doctors capable of understanding the interplay between upper and lower airway inflammation.
ISSN: 0040-6376
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Environment and Health - miscellaneous
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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