Title: Integrated miRNA and mRNA Expression Profiling in Inflamed Colon of Patients with Ulcerative Colitis
Authors: Van der Goten, Jan
Vanhove, Wiebe
Lemaire, Katleen
Machiels, Kathleen
Van Lommel, Leentje
De Preter, Vicky
De Hertogh, Gert
Wollants, Willem-Jan
Ferrante, Marc
Van Assche, Gert
Rutgeerts, Paul
Schuit, Frans
Vermeire, Severine
Arijs, Ingrid # ×
Issue Date: 29-Dec-2014
Publisher: Public Library of Sciene
Series Title: PLoS One vol:9 issue:12
Article number: e116117
Abstract: Ulcerative colitis (UC) is associated with differential colonic expression of genes involved in immune response (e.g. IL8) and barrier integrity (e.g. cadherins). MicroRNAs (miRNAs) are regulators of gene expression and are involved in various immune-related diseases. In this study, we investigated (1) if miRNA expression in UC mucosa is altered and (2) if any of these changes correlate with mucosal mRNA expression. Integration of mRNA and miRNA expression profiling may allow the identification of functional links between dysregulated miRNAs and their target mRNA.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Cell & Tissue Research
Department of Health and Technology - UC Leuven
Gene Expression Unit
Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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