Title: The involvement of the left motor cortex in learning of a novel action word lexicon
Authors: Liuzzi, Gianpiero ×
Freundlieb, Nils
Ridder, Volker
Hoppe, Julia
Heise, Kirstin
Zimerman, Maximo
Dobel, Christian
Enriquez-Geppert, Stefanie
Gerloff, Christian
Zwitserlood, Pienie
Hummel, Friedhelm C #
Issue Date: Oct-2010
Publisher: Current Biology Ltd.
Series Title: Current Biology vol:20 issue:19 pages:1745-51
Article number: 10.1016/j.cub.2010.08.034
Abstract: Current theoretical positions assume that action-related word meanings are established by functional connections between perisylvian language areas and the motor cortex (MC) according to Hebb's associative learning principle. To test this assumption, we probed the functional relevance of the left MC for learning of a novel action word vocabulary by disturbing neural plasticity in the MC with transcranial direct current stimulation (tDCS). In combination with tDCS, subjects learned a novel vocabulary of 76 concrete, body-related actions by means of an associative learning paradigm. Compared with a control condition with "sham" stimulation, cathodal tDCS reduced success rates in vocabulary acquisition, as shown by tests of novel action word translation into the native language. The analysis of learning behavior revealed a specific effect of cathodal tDCS on the ability to associatively couple actions with novel words. In contrast, we did not find these effects in control experiments, when tDCS was applied to the prefrontal cortex or when subjects learned object-related words. The present study lends direct evidence to the proposition that the left MC is causally involved in the acquisition of novel action-related words.
ISSN: 0960-9822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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