Title: Monitoring and optimising cognitive function in cancer patients: Present knowledge and future directions
Authors: Schagen, Sanne ×
Klein, Martin
Reijneveld, J.C
Brain, E.
Deprez, Sabine
Joly, Florence
Scherwath, A.
Schrauwen, W.
Wefel, J.S. #
Issue Date: 26-Mar-2014
Publisher: Pergamon/Elsevier
Series Title: European Journal of Cancer Supplements vol:12 pages:29-40
Abstract: The potentially detrimental effects of cancer and related treatments on cognitive functioning are emerging as a key focus of cancer survivorship research. Many patients with central nervous system (CNS) or non-CNS tumours develop cognitive problems during the course of their disease that can result in diminished functional independence. We review the state
of knowledge on the cognitive functioning of patients with primary and secondary brain
tumours at diagnosis, during and after therapy, and discuss current initiatives to diminish
cognitive decline in these patients. Similarly, attention is paid to the cognitive sequelae of
cancer and cancer therapies in patients without CNS disease. Disease and treatment effects
on cognition are discussed, as well as current insights into the neural substrates and the
mechanisms underlying cognitive dysfunction in these patients. In addition, rehabilitation
strategies for patients with non-CNS disease confronted with cognitive dysfunction are
described. Special attention is given to knowledge gaps in the area of cancer and cognition,
in CNS and non-CNS diseases. Finally, we point to the important role for cooperative groups
to include cognitive endpoints in clinical trials in order to accelerate our understanding and
treatment of cognitive dysfunction related to cancer and cancer therapies.
ISSN: 1359-6349
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Radiology
× corresponding author
# (joint) last author

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