ABO histo-blood group might modulate predisposition to Crohn's disease and affect disease behavior
Forni, Diego × Cleynen, Isabelle Ferrante, Marc Cassinotti, Andrea Cagliani, Rachele Ardizzone, Sandro Vermeire, Severine Fichera, Maria Lombardini, Marta Maconi, Giovanni de Franchis, Roberto Asselta, Rosanna Biasin, Mara Clerici, Mario Sironi, Manuela #
Elsevier Science BV
Journal of Crohns & Colitis vol:8 issue:6 pages:489-494
ABO encodes a glycosyltranferase which determines the major human histo-blood group. The FUT2 fucosyltransferase allows expression of ABO antigens on the gastrointestinal mucosa and in bodily secretions (secretor phenotype). A nonsense allele in FUT2 represents a susceptibility variant for Crohn's disease, and both the secretor and ABO blood group status affect the composition of the gut microbiota. Thus, we evaluated if variants in ABO might represent good candidates as Crohn's disease susceptibility loci.