Title: ABO histo-blood group might modulate predisposition to Crohn's disease and affect disease behavior
Authors: Forni, Diego ×
Cleynen, Isabelle
Ferrante, Marc
Cassinotti, Andrea
Cagliani, Rachele
Ardizzone, Sandro
Vermeire, Severine
Fichera, Maria
Lombardini, Marta
Maconi, Giovanni
de Franchis, Roberto
Asselta, Rosanna
Biasin, Mara
Clerici, Mario
Sironi, Manuela #
Issue Date: Jun-2014
Publisher: Elsevier Science BV
Series Title: Journal of Crohns & Colitis vol:8 issue:6 pages:489-494
Article number: 10.1016/j.crohns.2013.10.014
Abstract: ABO encodes a glycosyltranferase which determines the major human histo-blood group. The FUT2 fucosyltransferase allows expression of ABO antigens on the gastrointestinal mucosa and in bodily secretions (secretor phenotype). A nonsense allele in FUT2 represents a susceptibility variant for Crohn's disease, and both the secretor and ABO blood group status affect the composition of the gut microbiota. Thus, we evaluated if variants in ABO might represent good candidates as Crohn's disease susceptibility loci.
ISSN: 1873-9946
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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