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Title: An integrated approach for genome annotation of the eukaryotic thermophile Chaetomium thermophilum
Authors: Bock, Thomas ×
Chen, Wei-Hua
Ori, Alessandro
Malik, Nayab
Silva-Martin, Noella
Huerta-Cepas, Jaime
Powell, Sean T
Kastritis, Panagiotis L
Smyshlyaev, Georgy
Vonkova, Ivana
Kirkpatrick, Joanna
Doerks, Tobias
Nesme, Leo
Baßler, Jochen
Kos, Martin
Hurt, Ed
Carlomagno, Teresa
Gavin, Anne-Claude
Barabas, Orsolya
Müller, Christoph W
van Noort, Vera
Beck, Martin
Bork, Peer #
Issue Date: Dec-2014
Publisher: Oxford University Press
Series Title: Nucleic Acids Research vol:42 issue:22 pages:13525-13533
Article number: 10.1093/nar/gku1147
Abstract: The thermophilic fungus Chaetomium thermophilum holds great promise for structural biology. To increase the efficiency of its biochemical and structural characterization and to explore its thermophilic properties beyond those of individual proteins, we obtained transcriptomics and proteomics data, and integrated them with computational annotation methods and a multitude of biochemical experiments conducted by the structural biology community. We considerably improved the genome annotation of Chaetomium thermophilum and characterized the transcripts and expression of thousands of genes. We furthermore show that the composition and structure of the expressed proteome of Chaetomium thermophilum is similar to its mesophilic relatives. Data were deposited in a publicly available repository and provide a rich source to the structural biology community.
URI: 
ISSN: 0305-1048
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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