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Title: Validation and calibration of an electrical analog model of human liver perfusion based on hypothermic machine perfusion experiments
Authors: Debbaut, Charlotte ×
Monbaliu, Diethard
Segers, Patrick #
Issue Date: Jun-2014
Publisher: Wichtig Editore
Series Title: International Journal of Artificial Organs vol:37 issue:6 pages:486-98
Article number: 10.5301/ijao.5000337
Abstract: Hypothermic machine perfusion (HMP) is reviving as a better preservation method for donor livers than the golden standard of cold storage, but still faces challenges such as the risk for endothelial damage and flow competition between the arterial and portal venous inflow. Therefore, we previously developed an electrical analog model to investigate the effect of HMP settings on the human liver hemodynamics. While the model provided plausible results, it is based on a number of assumptions and its performance was never subjected to experimental validation. To this end, we present a new methodology to validate and calibrate this model to a specific liver.
ISSN: 0391-3988
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
× corresponding author
# (joint) last author

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