Title: Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
Authors: Van der Donckt, Carole ×
Van Herck, Jozef L
Schrijvers, Dorien M
Vanhoutte, Greetje
Verhoye, Marleen
Blockx, Ines
Van Der Linden, Annemie
Bauters, Dries
Lijnen, Roger
Sluimer, Judith C
Roth, Lynn
Van Hove, Cor E
Fransen, Paul
Knaapen, Michiel W
Hervent, Anne-Sophie
De Keulenaer, Gilles W
Bult, Hidde
Martinet, Wim
Herman, Arnold G
De Meyer, Guido R Y #
Issue Date: May-2015
Publisher: Oxford University Press
Series Title: European Heart Journal vol:36 issue:17 pages:1049-1058
Abstract: There is a need for animal models of plaque rupture. We previously reported that elastin fragmentation, due to a mutation (C1039G(+/-)) in the fibrillin-1 (Fbn1) gene, promotes atherogenesis and a highly unstable plaque phenotype in apolipoprotein E deficient (ApoE(-/-)) mice on a Western-type diet (WD). Here, we investigated whether plaque rupture occurred in ApoE(-/-)Fbn1(C1039G+/-) mice and was associated with myocardial infarction, stroke, and sudden death.
ISSN: 0195-668X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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