Title: Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice
Authors: Kruit, J K ×
Kremer, P H C
Dai, L
Tang, R
Ruddle, P
de Haan, Willeke
Brunham, L R
Verchere, C B
Hayden, M R #
Issue Date: Jun-2010
Publisher: Springer-Verlag Heidelberg
Series Title: Diabetologia vol:53 issue:6 pages:1110-9
Article number: 10.1007/s00125-010-1691-2
Abstract: Cellular cholesterol accumulation is an emerging mechanism for beta cell dysfunction in type 2 diabetes. Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol efflux leads to beta cell dysfunction. In this study, we aimed to determine the role of the LDL receptor (LDLr) in islet cholesterol uptake and to assess the contributions of cholesterol uptake compared with efflux to islet cholesterol levels.
ISSN: 0012-186X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science