Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages
Westerterp, Marit × Van Eck, Miranda de Haan, Willeke Offerman, Erik H Van Berkel, Theo J C Havekes, Louis M Rensen, Patrick C N #
Atherosclerosis vol:195 issue:1 pages:e9-16
Apolipoprotein CI (apoCI) is expressed in the liver and in macrophages, and has several roles in lipid metabolism. Since macrophage apoCI expression might affect macrophage lipid homeostasis and atherosclerotic lesion development locally in the arterial wall, we investigated the effect of both systemic and macrophage apoCI on atherosclerotic lesion development.