Title: Progression-free survival by local investigator versus independent central review: Comparative analysis of the AGO-OVAR16 Trial
Authors: Floquet, Anne ×
Vergote, Ignace
Colombo, Nicoletta
Fiane, Bent
Monk, Bradley J
Reinthaller, Alexander
Calvert, Paula
Herzog, Thomas J
Meier, Werner
Kim, Jae-Weon
Del Campo, Josep M
Friedlander, Michael
Pisano, Carmela
Isonishi, Seiji
Crescenzo, Rocco J
Barrett, Catherine
Wang, Karrie
Mitrica, Ionel
du Bois, Andreas #
Issue Date: Jan-2015
Publisher: Academic Press
Series Title: Gynecologic Oncology vol:136 issue:1 pages:37-42
Article number: 10.1016/j.ygyno.2014.11.074
Abstract: Analysis of progression-free survival (PFS) as the primary endpoint in advanced epithelial ovarian, fallopian tube, and primary peritoneal cancer (AEOC) trials may be confounded by the difficulty of radiologic evaluation of disease progression and the potential for discrepancy between investigator and blinded independent central assessments. PFS as assessed by local investigator (INV) was the primary endpoint of AGO-OVAR16, a randomized, double-blind trial of pazopanib maintenance therapy in AEOC. To confirm the robustness of the primary analysis, PFS was also evaluated by blinded independent central review (BICR).
ISSN: 0090-8258
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Gynaecological Oncology
× corresponding author
# (joint) last author

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