Title: Titanium implants with modified surfaces: Meta-analysis of in vivo osteointegration
Authors: Gasik, Michael ×
Braem, Annabel
Chaudhari, Amol
Duyck, Joke
Vleugels, Jef #
Issue Date: 24-Dec-2014
Publisher: Elsevier Sequoia
Series Title: Materials Science and Engineering C, Materials for Biological Applications vol:49 pages:152-158
Abstract: Titanium-based implants are widely used in modern clinical practice, but their “optimal” properties in terms of
porosity and topology, roughness and hydrophilic parameters are being a subject of intensive discussions. Recent
in vitro results have shown a possibility to optimize the surface of an implant with maximal repelling of bacteria
(Staphylococcus aureus, Staphylococcus epidermidis) and improvement in human osteogenic and endothelial cell
adhesion, proliferation and differentiation. In this work, these different grades titanium implants were tested in
vivo using the same analytical methodology. In addition to material parameters, key histomorphometrical
parameters such a regeneration area, bone adaptation area and bone-to-implant contact were determined
after 2 and 4 weeks of implantation in rabbit animal model. Porous implants have more clear differences than
non-porous ones, with the best optimum values obtained on hydrothermally treated electrophoretically deposited
titanium. These in vivo data correlate well with the optimal prediction made by in vitro tests.
ISSN: 0928-4931
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Materials Engineering - miscellaneous
Biomaterials - BIOMAT
Surface and Interface Engineered Materials
× corresponding author
# (joint) last author

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