Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

Dagklis, Antonis; Pauwels, Daphnie; Lahortiga, Idoya; Geerdens, Ellen; Bittoun, Emilie; Cauwelier, Barbara; Tousseyn, Thomas; Uyttebroeck, Anne; Maertens, Johan; Verhoef, Gregor; Vandenberghe, Peter; Cools, Jan

doi:10.3324/haematol.2014.119248

Hedgehog pathway mutations in T-cell acute lymphoblastic leukemia

Author:

Dagklis, Antonis

Pauwels, Daphnie ; Lahortiga, Idoya ; Geerdens, Ellen ; Bittoun, Emilie ; Cauwelier, Barbara ; Tousseyn, Thomas ; Uyttebroeck, Anne ; Maertens, Johan ; Verhoef, Gregor ; Vandenberghe, Peter ; Cools, Jan

Keywords:

Science & Technology, Life Sciences & Biomedicine, Hematology, Hedgehog pathway, leukemia, oncogene, signaling, DIFFERENTIATION, ACTIVATION, Adolescent, Adult, Animals, Base Sequence, Child, Female, Gene Expression, HEK293 Cells, Humans, Kruppel-Like Transcription Factors, Male, Mice, Inbred BALB C, Molecular Sequence Data, Mutation, Nerve Tissue Proteins, Patched Receptors, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Signal Transduction, Smoothened Receptor, T-Lymphocytes, Transcription Factors, Transduction, Genetic, Zinc Finger Protein GLI1, Zinc Finger Protein Gli3, 1102 Cardiorespiratory Medicine and Haematology, Immunology, 3201 Cardiovascular medicine and haematology