Title: Generation of a highly specific monoclonal anti-infliximab antibody for harmonization of TNF-coated infliximab assays
Authors: Van Stappen, Thomas
Brouwers, Els
Tops, Sophie
Geukens, Nick
Vermeire, Severine
Declerck, Paul
Gils, Ann # ×
Issue Date: Aug-2015
Publisher: Raven Press
Series Title: Therapeutic Drug Monitoring vol:37 issue:4 pages:479-85
Abstract: Determination of infliximab (IFX) serum concentrations has been used for treatment optimization of patients with inflammatory bowel disease (IBD). A wide range of ELISA assays exists to quantitate IFX. Most of these assays lack specificity and cross-react with other anti-tumor necrosis factor (TNF) agents. The ability of these IFX assays to detect IFX in complex with anti-drug antibodies is not known. The objective of our study was to develop an IFX-specific immunoassay to monitor IFX serum concentrations and to evaluate the impact of anti-drug antibodies on the assay performance.
ISSN: 0163-4356
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Therapeutic and Diagnostic Antibodies (+)
Translational Research in GastroIntestinal Disorders
Chemistry, Campus Kulak Kortrijk
× corresponding author
# (joint) last author

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