Title: A Multi-level Modeling Framework to Study Hepatic Perfusion Characteristics in case of Liver Cirrhosis
Authors: Peeters, Geert ×
Debbaut, Charlotte
Cornillie, Pieter
De Schryver, Thomas
Monbaliu, Diethard
Laleman, Wim
Segers, Patrick #
Issue Date: May-2015
Publisher: American Society of Mechanical Engineers
Series Title: Journal of Biomechanical Engineering vol:137 issue:5
Article number: 10.1115/1.4029280
Abstract: Liver cirrhosis represents the end-stage of different liver disorders, progressively affecting hepatic architecture, hemodynamics and function. Morphologically, cirrhosis is characterized by diffuse fibrosis, the conversion of normal liver architecture into structurally abnormal regenerative nodules and the formation of an abundant vascular network. To date, the vascular remodeling and altered hemodynamics due to cirrhosis are still poorly understood, even though they seem to play a pivotal role in cirrhogenesis. This study aims to determine the perfusion characteristics of the cirrhotic circulation using a multi-level modeling approach including computational fluid dynamics (CFD) simulations. Vascular corrosion casting and multi-level micro-CT imaging of a single human cirrhotic liver generated detailed datasets of the hepatic circulation, including typical pathological characteristics of cirrhosis such as shunt vessels and dilated sinusoids. Image processing resulted in anatomically correct 3D reconstructions of the microvasculature up to a diameter of about 500 µm. Subsequently, two cubic samples (150x150x150 µm3) were virtually dissected from vascularized zones in between regenerative nodules and applied for CFD simulations to study the altered cirrhotic microperfusion and permeability. Additionally, a conceptual 3D model of the cirrhotic macrocirculation was developed to reveal the hemodynamic impact of regenerative nodules. Our results illustrate that the cirrhotic microcirculation is characterized by an anisotropic permeability showing the highest value in the direction parallel to the central vein and lower values in the circumferential and radial direction. Overall, the observed permeabilities are markedly higher compared to a normal liver, implying a locally decreased intrahepatic vascular resistance (IVR) probably due to local compensation mechanisms (dilated sinusoids and shunt vessels). These counteract the IVR increase caused by the presence of regenerative nodules and dynamic contraction mechanisms (e.g. stellate cells, NO-concentration etc.). Our conceptual 3D model of the cirrhotic macrocirculation indicates that regenerative nodules severely increase the IVR beyond about 65 vol% of regenerative nodules. Numerical modeling allows quantifying perfusion characteristics of the cirrhotic macro- and microcirculation, i.e. the effect of regenerative nodules and compensation mechanisms such as dilated sinusoids and shunt vessels. Future research will focus on the development of models to study time-dependent degenerative adaptation of the cirrhotic macro- and microcirculation. Keywords. human liver cirrhosis, hepatic perfusion, computational fluid dynamics, permeability tensor.
ISSN: 0148-0731
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Abdominal Transplantation
Groep Gezondheid en Welzijn TM K - miscellaneous
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
A Multi-level Modeling Framework to Study Hepatic Perfusion Characteristics in case of Liver Cirrhosis.pdf Submitted 2865KbAdobe PDFView/Open


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science