Title: In vitro effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine, 5'-amino-5-iodo-2',5'-dideoxyuridine and 2-deoxy-D-glucose on latent ganglionic herpes simplex virus infection
Authors: Pavan-Langston, D ×
Park, N H
De Clercq, Erik #
Issue Date: Apr-1984
Publisher: Elsevier/North-Holland
Series Title: Antiviral Research vol:4 issue:1-2 pages:53-61
Abstract: (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) and 5'-amino-5-iodo-2',5'-dideoxy-uridine AIdUrd, blocked the reactivation of latent ganglionic herpes simplex virus in vitro. Furthermore, BVDU, but not AIdUrd, blocked the multiplication of reactivated latent virus and transiently suppressed emergence of reactivated virus from the sensory ganglia after removal of drug from the medium. 2-Deoxy-D-glucose (2-DG) neither prevented the in vitro reactivation of latent virus nor blocked the further multiplication of reactivated latent virus.
ISSN: 0166-3542
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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