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Title: Synthesis and biological evaluation of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine)
Authors: Schneller, S W ×
Luo, J K
Hosmane, R S
De Clercq, Erik
Stoeckler, J D
Agarwal, K C
Parks, R E
Saunders, P P #
Issue Date: Dec-1984
Publisher: ACS Publications
Series Title: Journal of Medicinal Chemistry vol:27 issue:12 pages:1737-9
Abstract: The synthesis of 6-amino-1H-pyrrolo[3,2-c]pyridin-4(5H)-one (3,7-dideazaguanine, 2) has been accomplished from 3-(ethoxycarbonyl)pyrrole-2-acetonitrile. In contrast to 3-deazaguanine, compound 2 did not show any antitumor, antiviral, or antibacterial properties. Furthermore, it was not a substrate for hypoxanthine-guanine phosphoribosyltransferase or purine nucleoside phosphorylase.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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