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Title: 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Authors: Li, Jingmei ×
Lindström, Linda S
Foo, Jia N
Rafiq, Sajjad
Schmidt, Marjanka K
Pharoah, Paul D P
Michailidou, Kyriaki
Dennis, Joe
Bolla, Manjeet K
Wang, Qin
Van 't Veer, Laura J
Cornelissen, Sten
Rutgers, Emiel
Southey, Melissa C
Apicella, Carmel
Dite, Gillian S
Hopper, John L
Fasching, Peter A
Haeberle, Lothar
Ekici, Arif B
Beckmann, Matthias W
Blomqvist, Carl
Muranen, Taru A
Aittomäki, Kristiina
Lindblom, Annika
Margolin, Sara
Mannermaa, Arto
Kosma, Veli-Matti
Hartikainen, Jaana M
Kataja, Vesa
Chenevix-Trench, Georgia
kConFab Investigators
Phillips, Kelly-Anne
McLachlan, Sue-Anne
Lambrechts, Diether
Thienpont, Bernard
Smeets, Ann
Wildiers, Hans
Chang-Claude, Jenny
Flesch-Janys, Dieter
Seibold, Petra
Rudolph, Anja
Giles, Graham G
Baglietto, Laura
Severi, Gianluca
Haiman, Christopher A
Henderson, Brian E
Schumacher, Fredrick
Le Marchand, Loic
Kristensen, Vessela
Alnæs, Grethe I Grenaker
Borresen-Dale, Anne-Lise
Nord, Silje
Winqvist, Robert
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Grip, Mervi
Andrulis, Irene L
Knight, Julia A
Glendon, Gord
Tchatchou, Sandrine
Devilee, Peter
Tollenaar, Robert
Seynaeve, Caroline
Hooning, Maartje
Kriege, Mieke
Hollestelle, Antoinette
van den Ouweland, Ans
Li, Yi
Hamann, Ute
Torres, Diana
Ulmer, Hans U
Rüdiger, Thomas
Shen, Chen-Yang
Hsiung, Chia-Ni
Wu, Pei-Ei
Chen, Shou-Tung
Teo, Soo Hwang
Taib, Nur Aishah Mohd
Har Yip, Cheng
Fuang Ho, Gwo
Matsuo, Keitaro
Ito, Hidemi
Iwata, Hiroji
Tajima, Kazuo
Kang, Daehee
Choi, Ji-Yeob
Park, Sue K
Yoo, Keun-Young
Maishman, Tom
Tapper, William J
Dunning, Alison
Shah, Mitul
Luben, Robert
Brown, Judith
Khor, Chiea Chuen
Eccles, Diana M
Nevanlinna, Heli
Easton, Douglas
Humphreys, Keith
Liu, Jianjun
Hall, Per
Czene, Kamila #
Issue Date: 2014
Series Title: Nature Communications vol:5 pages:4051
Article number: 10.1038/ncomms5051
Abstract: Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49-2.19); P for trend=1.90 × 10(-9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities.
ISSN: 2041-1723
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Translational Genetics (Vesalius Research Center) (+)
Surgical Oncology
Laboratory of Experimental Oncology
× corresponding author
# (joint) last author

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