ITEM METADATA RECORD
Title: Failure of athymic-nude mice sensitized with Bacillus Calmette-Guérin to produce interferon in response to purified protein derivative
Authors: Huygen, K ×
Zhen-Xi, Z
De Clercq, Erik #
Issue Date: Feb-1983
Publisher: Blackwell Science
Series Title: Proceedings of the Society for Experimental Biology and Medicine vol:172 issue:2 pages:260-4
Abstract: Unlike their +/+ and nu/+ littermates, homozygous athymic-nude (nu/nu) mice that had been sensitized with Bacillus Calmette-Guérin (BCG) failed to produce interferon (IFN) in response to purified protein derivative (PPD). Likewise, spleen cells derived from BCG-sensitized nu/nu mice failed to produce IFN when exposed to PPD in vitro. These findings suggest that the T-cell subset that responds to specific antigens (i.e., PPD) is absent in athymic-nude mice.
ISSN: 0037-9727
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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