Title: Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells
Authors: Bubley, G ×
Crumpacker, C
De Clercq, Erik
Schnipper, L #
Issue Date: Sep-1983
Publisher: Academic Press
Series Title: Virology vol:129 issue:2 pages:490-2
Abstract: (E)-5-(2-Bromovinyl)-2'-deoxyuridine (BVDU) is a highly selective inhibitor of herpes simplex virus-1 (HSV-1). A cell line (LH-1) expressing the HSV thymidine kinase (TK) gene is extremely sensitive to BVDU, whereas the parent line that expresses the cellular TK is resistant to BVDU. A TK-deficient derivative cell line (LMTK(-] which expresses neither the cellular nor viral TK was also extremely sensitive to BVDU. This suggests that the thymidine analog, BVDU, can be phosphorylated in thymidine kinase-deficient cells by pathways other than the cellular or HSV-encoded thymidine kinase.
ISSN: 0042-6822
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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