ITEM METADATA RECORD
Title: Synthesis and antiviral properties of (Z)-5-(2-bromovinyl)-2'-deoxyuridine
Authors: Jones, A S ×
Rahim, S G
Walker, R T
De Clercq, Erik #
Issue Date: Jun-1981
Publisher: ACS Publications
Series Title: Journal of Medicinal Chemistry vol:24 issue:6 pages:759-60
Abstract: (Z)-5-(2-Bromovinyl)uracil was obtained by photoisomerization of the E. isomer. Similarly, (E)-5-(2-bromovinyl)-2'-deoxyuridine gave the required Z isomer. (Z)-5-(2-Bromovinyl)-2'-deoxyuridine is much less active against herpes simplex virus type 1 (HSV-1) and somewhat less active against herpes simplex virus type 2 than is the E isomer. Both isomers show similar activity against vaccinia virus. Therefore, the highly potent and selective activity of (E)-5-(2-bromovinyl)-2'-deoxyuridine against HSV-1 is due to its E configuration.
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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