Title: Specific phosphorylation of E-5-(2-iodovinyl)-2'-deoxyuridine by herpes simplex virus-infected cells
Authors: Descamps, J ×
De Clercq, Erik #
Issue Date: Jun-1981
Publisher: American Society for Biochemistry and Molecular Biology
Series Title: Journal of Biological Chemistry vol:256 issue:12 pages:5973-6
Abstract: E-5-(2-Iodovinyl)-2'-deoxyuridine (IvdUrd), a highly selective and potent anti-herpes agent, is phosphorylated by primary rabbit kidney (PRK) cells that have been infected with either herpes simplex virus type 1 (KOS) or herpes simplex virus type 2 (G). However, IvdUrd is not phosphorylated by mock-infected PRK cells or PRK cells that have been infected with a thymidine kinase-deficient mutant of herpes simplex virus type 1 (B 2006). These observations strengthen the concept that the selectivity of IvdUrd and related E-5-(2-halogenovinyl)-2'-deoxyuridines as anti-herpes agents depends on a specific phosphorylation by the virus-encoded thymidine kinase.
ISSN: 0021-9258
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science