Title: Bio‐Based Nitriles from the Heterogeneously Catalyzed Oxidative Decarboxylation of Amino Acids
Authors: Claes, Laurens
Matthessen, Roman
Rombouts, Ine
Stassen, Ivo
De Baerdemaeker, Trees
Depla, Diederik
Delcour, Jan
Lagrain, Bert
De Vos, Dirk # ×
Issue Date: Jan-2015
Publisher: Wiley - V C H Verlag GmbH & Co. KGaA
Series Title: ChemSusChem: Chemistry & Sustainability, Energy & Materials vol:8 pages:345-352
Article number: cssc.201402801
Abstract: The oxidative decarboxylation of amino acids to nitriles was achieved in aqueous solution by in situ halide oxidation using catalytic amounts of tungstate exchanged on a [Ni,Al] layered double hydroxide (LDH), NH4Br, and H2O2 as the terminal oxidant. Both halide oxidation and oxidative decarboxylation were facilitated by proximity effects between the reactants and the LDH catalyst. A wide range of amino acids was converted with high yields, often >90 %. The nitrile selectivity was excellent, and the system is compatible with amide, alcohol, and in particular carboxylic acid, amine, and guanidine functional groups after appropriate neutralization. This heterogeneous catalytic system was applied successfully to convert a protein-rich byproduct from the starch industry into useful bio-based N-containing chemicals.
ISSN: 1864-5631
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Surface Chemistry and Catalysis
Centre for Food and Microbial Technology
× corresponding author
# (joint) last author

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