Synthesis and antiproliferative activity of 6-phenylaminopurines
Canela, María-Dolores × Liekens, Sandra Camarasa, María-José Priego, Eva María Pérez-Pérez, María-Jesús #
European Journal of Medicinal Chemistry vol:87 pages:421-8
A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative at position 6 of phenylaminopurine being the most active of the series in the six cell lines tested. Moreover, the compounds induced G2/M phase arrest in human cervical carcinoma HeLa cells as reported for tubulin depolymerizing agents.