Title: Synthesis and antiproliferative activity of 6-phenylaminopurines
Authors: Canela, María-Dolores ×
Liekens, Sandra
Camarasa, María-José
Priego, Eva María
Pérez-Pérez, María-Jesús #
Issue Date: Nov-2014
Series Title: European Journal of Medicinal Chemistry vol:87 pages:421-8
Article number: 10.1016/j.ejmech.2014.09.093
Abstract: A series of novel 6-phenylaminopurines have been efficiently synthesized in 3 steps exploring different groups at positions 2, 8 and 9 of the purine ring and at the exocyclic nitrogen atom at position 6. Among the newly described purines, five compounds showed antiproliferative activity with IC50 values below 10 μM, the tetrahydroquinoline derivative at position 6 of phenylaminopurine being the most active of the series in the six cell lines tested. Moreover, the compounds induced G2/M phase arrest in human cervical carcinoma HeLa cells as reported for tubulin depolymerizing agents.
ISSN: 0223-5234
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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