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Title: The spleen responds to intestinal manipulation but does not participate in the inflammatory response in a mouse model of postoperative ileus
Authors: Costes, Léa M M ×
van der Vliet, Jan
Farro, Giovanna
Matteoli, Gianluca
van Bree, Sjoerd H W
Olivier, Brenda J
Nolte, Martijn A
Boeckxstaens, Guy
Cailotto, Cathy #
Issue Date: 2014
Publisher: Public Library of Sciene
Series Title: PLoS One vol:9 issue:7 pages:e102211
Article number: 10.1371/journal.pone.0102211
Abstract: Postoperative ileus is characterized by a transient impairment of the gastrointestinal motility after abdominal surgery. The intestinal inflammation, triggered by handling of the intestine, is the main factor responsible for the prolonged dysmotility of the gastrointestinal tract. Secondary lymphoid organs of the intestine were identified as essential components in the dissemination of inflammation to the entire gastrointestinal tract also called field effect. The involvement of the spleen, however, remains unclear.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Translational Research in GastroIntestinal Disorders
× corresponding author
# (joint) last author

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