Title: Functional bioinformatics of microarray data: From expression to regulation
Authors: Moreau, Yves ×
De Smet, Frank
Thijs, Gert
Marchal, Kathleen
De Moor, Bart #
Issue Date: Nov-2002
Publisher: Institute of Electrical and Electronics Engineers
Series Title: Proceedings of the IEEE vol:90 issue:11 pages:1722-1743
Abstract: Using microarrays is a powerful technique to monitor the expression of thousands of genes in a single experiment. From series of such experiments, it is possible to identify the mechanisms that govern the activation of genes in an organism. Short deoxyribonucleic acid patterns (called binding sites) near the genes serve as switches that control gene expression. As a result similar patterns of expression can correspond to similar binding site patterns. Here we integrate clustering of coexpressed genes with the discovery of binding motifs. We overview several important clustering techniques and present a clustering algorithm (called adaptive quality-based clustering), which we have developed to address several shortcomings of existing methods. We overview the different techniques for motif finding, in particular the technique of Gibbs sampling, and we present several extensions of this technique in our Motif Sampler Finally, we present an integrated web tool called INCLUSive (available online at todna/BioI/Software.html) that allows the easy analysis of microarray data for motif finding.
ISSN: 0018-9219
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Electrical Engineering - miscellaneous
Vesalius Research Centre (-)
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics
Environment and Health - miscellaneous
× corresponding author
# (joint) last author

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