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Title: Amyloid PET in clinical practice: Its place in the multidimensional space of Alzheimer's disease
Authors: Vandenberghe, Rik ×
Adamczuk, Katarzyna
Dupont, Patrick
Van Laere, Koen
Chételat, Gaël #
Issue Date: 6-Apr-2013
Publisher: Elsevier BV
Series Title: NeuroImage: Clinical vol:2 pages:497-511
Abstract: Amyloid imaging is currently introduced to the market for clinical use. We will review the evidence demonstrating
that the different amyloid PET ligands that are currently available are valid biomarkers for Alzheimer-related β amyloidosis. Based on recent findings from cross-sectional and longitudinal imaging studies using different modalities, we will incorporate amyloid imaging into a multidimensional model of Alzheimer's disease. Aside from the critical role in improving clinical trial design for amyloid-lowering drugs, we will also propose a tentative algorithm for when it may be useful in a memory clinic environment. Gaps in our evidence-based knowledge of the added value of amyloid imaging in a clinical context will be
identified and will need to be addressed by dedicated studies of clinical utility.
ISSN: 2213-1582
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Cognitive Neurology
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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