Title: [Interferon induction increased through chemical modification of a synthetic polyribonucleotide]
Authors: De Clercq, Erik ×
Eckstein, E
Merigan, T C #
Issue Date: Sep-1969
Publisher: American Association for the Advancement of Science
Series Title: Science vol:165 issue:3898 pages:1137-9
Abstract: The alternating copolymer riboadenylic-ribouridylic acid gained asignificant increase in ability to stimulate interferon production (2-to 20-fold) and cellular resistance (100-to 10,000-fold) both in vitro and in vivo upon substitution of phosphate by thiophosphate groups. The resulting nucleotide analog was also 10 to 100 times less sensitive to degradation by pancreatic ribonuclease, as determined byresidual antiviral activity.
ISSN: 0036-8075
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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