Title: High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study
Authors: Terwijn, Monique ×
van Putten, Wim L J
Kelder, Angèle
van der Velden, Vincent H J
Brooimans, Rik A
Pabst, Thomas
Maertens, Johan
Boeckx, Nancy
de Greef, Georgine E
Valk, Peter J M
Preijers, Frank W M B
Huijgens, Peter C
Dräger, Angelika M
Schanz, Urs
Jongen-Lavrecic, Mojca
Biemond, Bart J
Passweg, Jakob R
van Gelder, Michel
Wijermans, Pierre
Graux, Carlos
Bargetzi, Mario
Legdeur, Marie-Cecile
Kuball, Jurgen
de Weerdt, Okke
Chalandon, Yves
Hess, Urs
Verdonck, Leo F
Gratama, Jan W
Oussoren, Yvonne J M
Scholten, Willemijn J
Slomp, Jennita
Snel, Alexander N
Vekemans, Marie-Christiane
Löwenberg, Bob
Ossenkoppele, Gert J
Schuurhuis, Gerrit J #
Issue Date: Nov-2013
Publisher: Grune & Stratton
Series Title: Journal of Clinical Oncology vol:31 issue:31 pages:3889-97
Article number: 10.1200/JCO.2012.45.9628
Abstract: Half the patients with acute myeloid leukemia (AML) who achieve complete remission (CR), ultimately relapse. Residual treatment-surviving leukemia is considered responsible for the outgrowth of AML. In many retrospective studies, detection of minimal residual disease (MRD) has been shown to enable identification of these poor-outcome patients by showing its independent prognostic impact. Most studies focus on molecular markers or analyze data in retrospect. This study establishes the value of immunophenotypically assessed MRD in the context of a multicenter clinical trial in adult AML with sample collection and analysis performed in a few specialized centers.
ISSN: 0732-183X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Experimental Hematology (+)
Department of Health and Technology - UC Leuven
Laboratory of Clinical Bacteriology and Mycology
× corresponding author
# (joint) last author

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