Patient-derived xenograft models: an emerging platform for translational cancer research
Hidalgo, Manuel × Amant, Frédéric Biankin, Andrew V Budinská, Eva Byrne, Annette T Caldas, Carlos Clarke, Robert B de Jong, Steven Jonkers, Jos Mælandsmo, Gunhild Mari Roman-Roman, Sergio Seoane, Joan Trusolino, Livio Villanueva, Alberto #
Cancer discovery vol:4 issue:9 pages:998-1013
Recently, there has been an increasing interest in the development and characterization of patient-derived tumor xenograft (PDX) models for cancer research. PDX models mostly retain the principal histologic and genetic characteristics of their donor tumor and remain stable across passages. These models have been shown to be predictive of clinical outcomes and are being used for preclinical drug evaluation, biomarker identification, biologic studies, and personalized medicine strategies. This article summarizes the current state of the art in this field, including methodologic issues, available collections, practical applications, challenges and shortcomings, and future directions, and introduces a European consortium of PDX models.