Relative potencies of different anti-herpes agents in the topical treatment of cutaneous herpes simplex virus infection of athymic nude mice
Descamps, J × De Clercq, Erik Barr, P J Jones, A S Walker, R T Torrence, P F Shugar, D #
American Society for Microbiology (ASM)
Antimicrobial Agents and Chemotherapy vol:16 issue:5 pages:680-2
Thirteen established anti-herpes compounds have been directly compared in a single assay system for their effects on the development of herpetic skin lesions, and mortality associated therewith, in athymic nude (nu/nu) mice inoculated intracutaneously with herpes simplex virus type 1 (KOS). When applied topically (at 1% in a water-soluble ointment), phosphonoacetic acid, E-5-(2-bromovinyl)-2'-deoxyuridine, acycloguanosine, and trisodium phosphonoformate emerged as the most active agents.