Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data

Di Narzo, Antonio F; Tejpar, Sabine; Rossi, Simona; Yan, Pu; Popovici, Vlad; Wirapati, Pratyaksha; Budinska, Eva; Xie, Tao; Estrella, Heather; Pavlicek, Adam; Mao, Mao; Martin, Eric; Scott, Weinrich; Bosman, Fred T; Roth, Arnaud; Delorenzi, Mauro

doi:10.1093/jnci/dju247

Test of Four Colon Cancer Risk-Scores in Formalin Fixed Paraffin Embedded Microarray Gene Expression Data

Author:

Di Narzo, Antonio F

Tejpar, Sabine ; Rossi, Simona ; Yan, Pu ; Popovici, Vlad ; Wirapati, Pratyaksha ; Budinska, Eva ; Xie, Tao ; Estrella, Heather ; Pavlicek, Adam ; Mao, Mao ; Martin, Eric ; Scott, Weinrich ; Bosman, Fred T ; Roth, Arnaud ; Delorenzi, Mauro

Keywords:

Science & Technology, Life Sciences & Biomedicine, Oncology, STAGE-II, COLORECTAL-CANCER, PREDICT RECURRENCE, ADJUVANT TREATMENT, POOR-PROGNOSIS, VALIDATION, TRIAL, ASSAY, PETACC-3, MARKER, Adenocarcinoma, Adult, Aged, Antineoplastic Agents, Area Under Curve, Biomarkers, Tumor, Colonic Neoplasms, Disease-Free Survival, Female, Fixatives, Formaldehyde, Gene Expression Regulation, Neoplastic, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Paraffin, Predictive Value of Tests, Prognosis, Proportional Hazards Models, ROC Curve, Randomized Controlled Trials as Topic, Risk Assessment, Risk Factors, Tissue Array Analysis, Transcriptome, Treatment Failure, 1112 Oncology and Carcinogenesis, Oncology & Carcinogenesis, 3211 Oncology and carcinogenesis

Abstract:

Prognosis prediction for resected primary colon cancer is based on the T-stage Node Metastasis (TNM) staging system. We investigated if four well-documented gene expression risk scores can improve patient stratification.