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Title: Functional Histology of Salivary Gland Pleomorphic Adenoma: An Appraisal
Authors: Triantafyllou, Asterios ×
Thompson, Lester D R
Devaney, Kenneth O
Bell, Diana
Hunt, Jennifer L
Rinaldo, Alessandra
Vander Poorten, Vincent
Ferlito, Alfio #
Issue Date: Sep-2015
Publisher: Humana Press Inc.
Series Title: Head and Neck Pathology vol:9 issue:3 pages:387-404
Abstract: The complex microstructure of salivary gland pleomorphic adenoma is examined in relation to function. Events related to secretion of macromolecules and absorption, responses to the altered microenvironment and controversies concerning epithelial-mesenchymal transition versus modified myoepithelial differentiation are explored. Their effects on tumor cell phenotypes and arrangements are emphasized. Heterotopic differentiation and attempts at organogenesis are also considered. The approach allows interpreting microstructure independently of histogenetic perceptions, envisaging the tumor cells as a continuum, endorsing luminal structures as the principal components, and defining pleomorphic adenoma as a benign epithelial tumour characterized by variable epithelial-mesenchymal transition, secretion/differentiation and metaplasia.
URI: 
ISSN: 1936-0568
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Head and Neck Oncology (+)
× corresponding author
# (joint) last author

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